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    Nitu Malladi, Thu, 03/02/2017 - 09:09:

    But drinking coffee shortly after waking up, as it turns out, is actually a bit counterproductive. Not only does it undermine the caffeine's effect, but it tends to lead people to build a tolerance for the drug, thereby diminishing its effect down the road.

    Our bodies produce a hormone called cortisol, which has been branded the "stress hormone," because it tends to appear when we are either stressed or fearful. But that same hormone is also a key component of our natural, day-long hormonal cycle, known as the circadian clock, which helps wake us up in the morning and wind us down at night. The gist is that when our body releases cortisol, we feel more awake.There are two basic problems with consuming caffeine when cortisol production is high. First, caffeine tends to interfere with the production of cortisol. The body then produces less of the hormone and relies more on the caffeine.Second, drinking coffee while cortisol is high leads us to develop long-term tolerances for caffeine, which is why so many habitual coffee drinkers say it has less of an effect on them. In effect, caffeine replaces the boost we would ordinarily get from cortisol rather than supplementing it.Second, drinking coffee while cortisol is high leads us to develop long-term tolerances for caffeine, which is why so many habitual coffee drinkers say it has less of an effect on them. In effect, caffeine replaces the boost we would ordinarily get from cortisol rather than supplementing it.It's during the troughs above — between roughly 10 a.m. and noon, and 2 p.m. and 5 p.m.—when people should drink coffee if they want to get the most out of their caffeine. Between those hours, the coffee is actually most needed, and, perhaps most importantly, will not interfere with our body's own essential mechanism for keeping us alert.

    Studies have shown that when people talk about developing a "tolerance" for coffee, they are often talking — albe it unknowingly — about the reality that their coffee consumption has fostered a decrease in the amount of cortisol their body produces during the day.